Research and latest developments: What’s on the horizon for PF

This resource, research and latest developments: what’s on the horizon for pulmonary fibrosis, is a recording of the patient session presented at the Australasian Rare Lung Disease Conference. Pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF), often results from genetic predispositions combined with environmental factors like dust or smoke exposure. Advances in understanding the genetic and cellular mechanisms, such as the role of telomeres and macrophages, are paving the way for new treatments. Current efforts focus on anti-fibrotic drugs, but future therapies aim to target upstream pathways and genetic causes. Clinical trials are crucial for accessing these emerging treatments. The PACT network connects patients with clinical trials, ensuring they benefit from the latest research and therapies.

Advances in PF treatment are promising, with potential to reverse accelerated lung aging. Rejuvenation Technologies is developing an mRNA therapeutic that delivers an enzyme to lengthen telomeres in lung stem cells via the bloodstream. This treatment has shown to reverse about seven years of aging in human cells with a single dose and is set for clinical trials by the end of next year. Additionally, a small molecule treatment to lengthen telomeres, involving a synthetic androgen called danazol, is currently in trials. mRNA therapeutics, similar to COVID-19 vaccine technology, deliver proteins to specific cells, offering a revolutionary approach to medicine. This method uses lipid nanoparticles to transport mRNA to lung cells, where it is translated into proteins that lengthen telomeres.

There are numerous promising new antifibrotic treatments in various phases of clinical trials. Some of these trials are expected to yield positive results within the next year or two, potentially offering new antifibrotics with fewer side effects and greater effectiveness. Alongside these treatments, advancements in diagnostic methods will help reduce the time to diagnosis, ensuring patients receive accurate and timely treatment. Understanding the exact cause of the disease in each individual is crucial for delivering effective treatments.