Immune regulation of Idiopathic Pulmonary Fibrosis

For Tylah Miles, research means hope that patients can live a long and happy life with their loved ones.

What are some of the key findings, progress and discoveries you have made with your research to date – and how will this make a difference to patients with this disease?  

We have discovered a specific immune cell signature that identifies that a sub-group of patients who were initially diagnosed with Idiopathic Pulmonary Fibrosis (IPF), also present with autoimmune-like features. Although further validation is needed, this signature may be useful in identifying this group of patients early. It is possible that these individuals with altered immune responses may be more likely to respond to treatment with immunotherapy. 

For Tylah Miles, research means new discoveries and new treatments. 

What do you hope to achieve with this research project? 

Our research investigates the cell-mediated responses driving lung fibrosis. In our laboratory we combine the analysis of pre-clinical models of disease with the detailed analysis of patient samples. Specifically, we are investigating the functional role of immune cells in the development and progression of lung fibrosis. We hope that in time, identifying how these cells contribute to IPF will lead to the discovery of potential novel therapeutic targets. 

For Tylah Miles, research means improving the quality of life for people with lung diseases. 

How important was the funding from Lung Foundation Australia to your work? 

This research project forms the basis of my PhD studies, which are jointly funded by a Research Training Program Scholarship from the University of Western Australia and the Lung Foundation Australia Bill van Nierop PhD Scholarship in IPF. 

Funding from Lung Foundation Australia allowed me to work full-time focusing on the role of immune cells in lung fibrosis. 

Do you have a message for Lung Foundation Australia’s supporters? 

Our laboratory–based research relies heavily on grant funding, your fundraising efforts as well as your participation in our clinical sample collection. We would like to thank you, the Lung Foundation Australia’s supporters, for your ongoing support and encouragement. Together we will reduce the burden of chronic respiratory disorders.