The webinar presented by Steven Kao, a Medical Oncologist, provides comprehensive information about genetic testing in lung cancer. Genetic testing is a crucial tool in the diagnosis and treatment of lung cancer, offering insights into the specific mutations driving the disease and guiding personalized treatment plans.
What is Genetic Testing in Lung Cancer? Genetic testing, also known as genomic or biomarker testing, involves analysing a sample of cancer cells to identify specific genetic mutations. These mutations can influence how cancer cells grow, divide, and respond to treatments. By identifying these mutations, doctors can tailor treatments to target the cancer more effectively.
Which Mutations are Relevant in Lung Cancer? Several genetic mutations are commonly associated with lung cancer. The most notable include:
- EGFR (Epidermal Growth Factor Receptor): Mutations in the EGFR gene can cause cells to grow and divide uncontrollably. These mutations are found in about 10% of non-small cell lung cancer (NSCLC) cases
- KRAS: This gene mutation is present in approximately 25% of NSCLC cases and is associated with resistance to certain therapies
- ALK (Anaplastic Lymphoma Kinase): ALK mutations are found in about 5% of NSCLC cases and can be targeted with specific therapies
- TP53: This gene helps regulate cell division and apoptosis. Mutations in TP53 are found in a significant number of lung cancer cases
Who Gets Genetic Testing? Genetic testing is typically recommended for patients diagnosed with non-small cell lung cancer (NSCLC). It is particularly important for those with advanced-stage cancer, as identifying specific mutations can help determine the most effective treatment options.
When is Genetic Testing Done? Genetic testing is usually performed at the time of diagnosis or when the cancer recurs after initial treatment. It is an integral part of the diagnostic process, helping to stage the cancer and guide treatment decisions.
How is Genetic Testing Done? The process involves obtaining a sample of the tumour tissue, usually through a biopsy. The sample is then analysed in a laboratory to identify any genetic mutations. Advanced techniques such as next-generation sequencing (NGS) can screen for multiple mutations simultaneously, providing a comprehensive genetic profile of the cancer.
Importance of Genetic Testing: Genetic testing plays a vital role in the era of personalized medicine. By understanding the genetic makeup of a tumour, doctors can select targeted therapies that are more likely to be effective. This approach not only improves treatment outcomes but also minimizes unnecessary side effects.
Support and Resources: For further support, patients and carers can contact the Lung Foundation Australia’s Information and Support Centre at 1800 654 301. They offer resources and support to help manage the challenges of living with lung cancer. This includes access to specialist nurses, support groups, and educational materials that can provide valuable information and emotional support.
In summary, genetic testing is a powerful tool in the fight against lung cancer. It helps identify specific mutations that drive the disease, guiding personalized treatment plans that improve patient outcomes. Understanding the role of genetic testing can empower patients and their families to make informed decisions about their care. For more information and support, contact Lung Foundation Australia at 1800 654 301 or visit their website.
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